Oral and intravenous administration Similar to third-generation quinolones but with improved gram-positive coverage and added anaerobic coverage Consider for treatment of intra-abdominal infections.
Ampicillin/sulbactam was given to 24 patients, cefoxitin to 16 and cefazolin to 12 patients. Analysis of clinical and bacteriological responses showed no significant differences between groups despite the fact that by in vitro testing 82 (98%) of isolates from soft-tissue infections were susceptible to ampicillin/sulbactam but only 68 (81%) were susceptible to cefoxitin (p < 0.001).
The Centers for Disease Control and Prevention (CDC) guidelines do not recommend double anaerobic coverage, and no evidence exists to show that double anaerobic coverage in PID results in better clinical or microbiologic cure rates. Studies done in the 1980s found cefoxitin to be effective in eradication of anaerobic infections (80 – 82). It has often been used for surgical prophylaxis at most body sites that are in proximity to mucus membranes. Many infections caused by mixtures of susceptible aerobic and anaerobic bacteria respond to treatment with Cefoxitin. Cefoxitin for injection is indicated for the treatment of serious infections caused by susceptible strains of the designated microorganisms in the diseases listed below.
2013-07-01 Cefoxitin Moxifloxacin (non-formulary) All Carbapenems (meropenem, ertapenem, imipenem) Guidelines as well as susceptibility and clinical data DO NOT SUPPORT double-anaerobic coverage. anaerobic coverage to antibiotics already with anaerobic activity HAS NOT been shown to improve clinical outcomes in patients. Anti-Anaerobic Antimicrobial Agents: Cefoxitin, Cefotetan, Clindamycin, and Metronidazole. February 1990; Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Cefoxitin every 3 hours coverage for Enterococcus or Pseudomonas. GI: Appendectomy.
have summarized several PID trials in a recent article.9 The therapies and their respective clinical cure rates were: ofloxacin (95%) vs. cefoxitin plus doxycycline (93%); Use of Cefoxitin, New Cephalosporin-Like Antibiotic, in the Treatment of Aerobic and Anaerobic Infections S. Ramachandran Nair †, 1 and Charles E. Cherubin 1 1 Infectious Disease Department and Microbiology Laboratory, Jewish Hospital, Brooklyn, New York 11238 Cefoxitin is a second-generation cephamycin antibiotic developed by Merck & Co., Inc. from Cephamycin C in the year following its discovery, 1972.
2010-09-15 · Coverage for obligate anaerobic bacilli should be provided for dis-tal small bowel, appendiceal, and colon-derived infection cefoxitin, ertapenem (Invanz), moxifloxacin (Avelox),
The Centers for Disease Control and Prevention (CDC) guidelines do not recommend double anaerobic coverage, and no evidence exists to show that double anaerobic coverage in PID results in better clinical or microbiologic cure rates. Studies done in the 1980s found cefoxitin to be effective in eradication of anaerobic infections (80 – 82). It has often been used for surgical prophylaxis at most body sites that are in proximity to mucus membranes. Many infections caused by mixtures of susceptible aerobic and anaerobic bacteria respond to treatment with Cefoxitin.
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While cefoxitin has better anaerobic coverage, ceftriaxone has better coverage against N. gonorrhoeae. Follow-up includes evaluation by a health-care provider within 3 days to insure clinical improvement. Lack of improvement might require hospitalization, additional tests, or surgical intervention.
Cefoxitin and cefotetan also have some anaerobic activity. Patients with reported antibiotic allergy have… Treatment of osteomyelitis due to nontuberculous mycobacteria in adults View in Chinese
Cefoxitin (IV – Mefoxin) Increased anaerobic activity, including excellent B fragilis coverage Cefotetan (IV – Cefotan) Anaerobes, including B fragilis Third Generation Cefotaxime (IV – Claforan) Ceftriaxone (IV – Rocephin) Meningitis and gram negative sepsis Excellent gram negative activity including all Enterobacteriaceae
2021-01-22 · Many infections caused by mixtures of susceptible aerobic and anaerobic bacteria respond to treatment with Cefoxitin.
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Bosso,PharmD RandallA. Prince, PharmD Anaerobic bacteria are … 1989-12-01 Cefoxitin therapy of anaerobic and aerobic infections.
In clinical studies in patients with intra-abdominal infections caused by Bacteroides (i.e.,B. distasonis, B. fragilis, B. ovatus, B. thetaiotaomicron), eradication rates 1-2 weeks after cefoxitin therapy have been reported to be 70-80%.
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Gram-negative bacteria . Eikenella corrodens (non-β-lactamase producers) Anaerobic bacteria 2020-02-27 · Cefoxitin for Injection, USP, like cephalosporins, has no activity against Chlamydia trachomatis. Therefore, when Cefoxitin for Injection, USP is used in the treatment of patients with pelvic inflammatory disease and C. trachomatis is one of the suspected pathogens, appropriate anti-chlamydial coverage should be added. Anti-Anaerobic AntimicrobialAgents: Cefoxitin,Cefotetan, Clindamycin,and Metronidazole JohnA.